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May 25, 2009

onemoredietWe have all been tempted to take weight loss medications that reduce or control weight, haven’t we?  But do you actually know how they work to help you lose weight?  Here’s how: they affect weight regulation by altering your appetite, metabolism or the absorption of calories.  Take the example of Phentermine.  Phentermine’s mechanism is similar to that of an amphetamine; it works by stimulating the central nervous system (nerves and brain), which increases your heart rate and blood pressure and decreases your appetite. It acts to stimulate the hypothalamus gland and affects certain neurotransmitters, and also works outside the brain to release epinephrine or adrenaline which causes fat cells to break down.

Other medications, such as Xenical, work on the digestive system to actually block fat in the food you eat from being digested by the digestive enzyme called lipase.  When taken with meals, Xenical attaches to lipase and blocks it from breaking down some of the fat you have eaten; and then the undigested fat is then eliminated in your stools.

Meridia/Reductil or sibutramine works by increasing the activity of norepinephrine and serotonin, in the brain which helps regulate the sense of fullness or your signal to stop eating, making you satisfied with less food.  The active ingredient, sibutramine, works by acting on the appetite control center in the brain where the satiety signal is activated.

Combining these powerful weight-loss drugs with a low-calorie diet and regular exercise can help you lose more weight than can either drugs or lifestyle changes alone.  And get this: combining all three can help you lose anywhere from 5 percent to 10 percent of your total body weight within a year.   This may not seem like many pounds lost, but even modest weight loss has a significant benefit to your health. Losing just a small percentage of your weight can decrease blood pressure, triglyceride levels, blood glucose levels and insulin levels.

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